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Activated Hepatic Stellate Cell Diagram in Liver Fibrosis Process

Liver fibrosis is a dynamic process resulting in excessive deposition of extracellular matrix (ECM) components. It is considered a common response to many chronic hepatic injuries which involves several cell types, cytokines, chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem. The picture shows you with diagram of activated hepatic stellate cell actions and interactions in liver fi…

Category: Endocrinologist, Pathophysiology | Tags: , , | 10:30 am | comments 0 Comments

A Physiopathological Mechanism for Postmenopausal Bone Loss in Osteoporotic Women

An imbalance between bone formation and bone resorption is thought to underlie the pathogenesis of reduced bone mass (bone loss) in osteoporosis. A study which evaluated a possibilities increase in spontaneous osteoclast formation in postmenopausal osteoporotic women is described below.   The schematic diagram demonstrates an increase in the production of RANKL and TNF-A by PBMC of osteoporotic women with respect to controls. This study al…

Category: Pathophysiology | Tags: , , , | 9:48 am | comments 0 Comments