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Cushing’s Syndrome Pathophysiology Diagram and Guideline

negative feedback servo mechanism diagram of Cushing's Syndrome

Cushing’s Syndrome (hypercortisolism) is hormonal disorder caused by prolonged exposure of the body’s tissues to high levels of the hormone cortisol which can be from both serum ACTH low (iatrogenic, adrenal neoplasm) and serum ACTH high (pituitary neoplasm, ectopic ACTH). The pathophysiology diagram of Cushing’s Syndrome can be understood through the above illustration, since the outcome of this cycle is people develop Cushing’s syndrome becau…

How-to Calculate the Creatinine Clearance using Cockcroft-Gault

ulations. Calculation of Cockcroft-Gault Creatinine Clearance as an estimate of Glomerulo Filtration Rate/GFR (ml/min): Where F = 1.23 (male), F = 1.04 (female). Notes: If patient is anuric, morbidly obese or in acute renal failure (ARF), this equation will NOT give a true reflection of creatinine clearance. (source: nuh.nhs.uk) …