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Children Sickle Cell Disease Management Guideline for Paediatrics Physician

The folowing physician guideline provides direction for the management of children with sickle cell disease who present to the emergency department with complications of their condition (Acute Painful Episodes, Fever, Acute Chest Syndrome or Pneumonia). You will be prensented with sections such General Recommendations for the Management of Paediatric Sickle Cell Disease, Guideline for Acute Painful Episode (Vaso Occlusive Disease), the manageme…

Bone Remodeling and Pathogenesis of Glucocorticoid-Induced Bone Disease

The pathophysiology of glucocorticoid-induced bone disease involve interactions with calcium and bone metabolism at multiple levels with both direct and indirect effects which impact on osteoblasts and osteoclasts. See informations about glucocorticoid-induced osteoporosis (the cellular changes, bone histomorphometry) in this journal. The balance between bone resorption, bone formation and bone cell proliferation (as seen in the picture), which…