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Bone Remodeling and Pathogenesis of Glucocorticoid-Induced Bone Disease

The pathophysiology of glucocorticoid-induced bone disease involve interactions with calcium and bone metabolism at multiple levels with both direct and indirect effects which impact on osteoblasts and osteoclasts. See informations about glucocorticoid-induced osteoporosis (the cellular changes, bone histomorphometry) in this journal. The balance between bone resorption, bone formation and bone cell proliferation (as seen in the picture), which…

Understanding the Mechanisms and the Role of Glutathione in Lens Metabolism

glutathione-metabolism-pathway-diagram.png

Electrolyte disturbances which resulted an osmotic imbalances characterized the cataracts. It is important to understand the role glutatione and its enzime co-factors play in the metabolism within the lens. As seen in the figure below, glutathione is composed of the amino acids cysteine, glutamic acid, and glycine and its synthesis within the lens takes place in two steps. The description of this sections are clearly described in this document….