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Bone Marrow Failure Syndroms in the Pathophysiology Concept of Aplastic Anemia

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Aplastic anemia is an immune-mediated disease where bone marrow does not produce sufficient new cells to replenish blood cells in the paradigm of the human bone marrow failure syndroms (wikipedia). Hematopoietic stem-cell compartment is the target for the immune response in the pathophysiology concept of Aplastic anemia. The following figure shows the immune destruction of hematopoiesis occured. Sections such Clinical associations, Pathophysiol…

Category: Hematology, Pathophysiology | Tags: , , | 9:21 am | comments 0 Comments

Cardiogenic Shock Diagnosis and Pathophysiology Diagram

A systolic blood pressure less than 90mmHg due to hypoperfusion commonly defined as Cardiogenic shock. The hemodynamic criterias of cardiogenic shock cannot be separated from the fundamental aspects of normal cardiac function in the pathophysiology that leads to this shock (as shown in the diagram). It consists clinical criteria and hemodynamic criteria to have diagnosis of cardiogenic shock according to this journal. The clinical criterias are…

Category: Cardiologist | Tags: , , | 8:38 am | comments 0 Comments