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Pathophysiology of Chronic Alcoholic Pancreatitis

Pancreatitis due to alcohol abuse is a very painful and potentially fatal condition. The following article reported the mechanisms of alcohol activating of signal transduction pathways related to the pathophysiology of chronic alcoholic pancreatitis. You’ll be described with oxidative and a non-oxidative pathway of the alcohol metabolism, genetic predisposition of acute and chronic pancreatitis, stimulatory effect on gastric acid secretio…

Category: Alcohol Withdrawal, Pathophysiology | Tags: , , | 12:58 pm | comments 0 Comments

Bone Marrow Failure Syndroms in the Pathophysiology Concept of Aplastic Anemia

aplastic-anemia-pathophysiology-diagram_thumb.jpg

Aplastic anemia is an immune-mediated disease where bone marrow does not produce sufficient new cells to replenish blood cells in the paradigm of the human bone marrow failure syndroms (wikipedia). Hematopoietic stem-cell compartment is the target for the immune response in the pathophysiology concept of Aplastic anemia. The following figure shows the immune destruction of hematopoiesis occured. Sections such Clinical associations, Pathophysiol…

Category: Hematology, Pathophysiology | Tags: , , | 9:21 am | comments 0 Comments