The factors involved in the pathogenesis of Cor Pulmonale in Chronic Obstructive Pulmonary Disease (COPD) can be seen in the following diagram. As seen in the pathogenesis of Cor Pulmonale diagram above, hypoxemia exerts an effect on the pulmonary vasculature separate from alveolar hypoxia, as does acidosis. The increased pulmonary vascular resistance is contibuted by the reduction in pulmonary capillary surface area caused by emphysema. Furthe…
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