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Renal Sodium Retention Compensatory Mechanism in Essential Hypertension

An overall scheme for acquired compensatory mechanism for renal sodium retention which could be a cause of essential hypertension is shown in picture below. The picture shows the diagram of various feedback loops that may be involved in the rise in blood pressure accompanies attempt in preventing plasma volume expansion when excessive is ingested relative to the innate ability of the kidneys to excrete a sodium load. (source: medind.nic.in) …

Category: Hypertension | Tags: , , , | 10:05 am | comments 0 Comments

A Physiopathological Mechanism for Postmenopausal Bone Loss in Osteoporotic Women

An imbalance between bone formation and bone resorption is thought to underlie the pathogenesis of reduced bone mass (bone loss) in osteoporosis. A study which evaluated a possibilities increase in spontaneous osteoclast formation in postmenopausal osteoporotic women is described below.   The schematic diagram demonstrates an increase in the production of RANKL and TNF-A by PBMC of osteoporotic women with respect to controls. This study al…

Category: Pathophysiology | Tags: , , , | 9:48 am | comments 0 Comments