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Bone Marrow Failure Syndroms in the Pathophysiology Concept of Aplastic Anemia

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Aplastic anemia is an immune-mediated disease where bone marrow does not produce sufficient new cells to replenish blood cells in the paradigm of the human bone marrow failure syndroms (wikipedia). Hematopoietic stem-cell compartment is the target for the immune response in the pathophysiology concept of Aplastic anemia. The following figure shows the immune destruction of hematopoiesis occured. Sections such Clinical associations, Pathophysiol…

Category: Hematology, Pathophysiology | Tags: , , | 9:21 am | comments 0 Comments

Renal Sodium Retention Compensatory Mechanism in Essential Hypertension

An overall scheme for acquired compensatory mechanism for renal sodium retention which could be a cause of essential hypertension is shown in picture below. The picture shows the diagram of various feedback loops that may be involved in the rise in blood pressure accompanies attempt in preventing plasma volume expansion when excessive is ingested relative to the innate ability of the kidneys to excrete a sodium load. (source: medind.nic.in) …

Category: Hypertension | Tags: , , , | 10:05 am | comments 0 Comments