The following guideline article contain materials related to evolving concept and new potential therapies of sepsis based on its pathophysiology and genetic basis for the host responses to the syndrome.
This pathophysiology diagram shows the response of many immune cells including macrophages, dendritic cells and CD4 T Cells. You can find the explanations of sections such as mechanism of immune suppression in sepsis, reappraisal of Lewis Thomas’ theory (uncontrolled hyperinflammation as body’s primary response to infection and injury), facts about neutrophils, the host genetic factors, cellular hibernation as mechanism of organ dysfunction, and new treatment concepts of sepsis.
Find detailed information here in the following Sepsis Treatment Guideline of pdf filetype (source: nejm.org)
