A hypertonic saline and traumatic brain injury has a close interconnection between. As an osmotherapeutic agent, hypertonic saline may have been used as possible substitutes for early known agent – manitol. A suggested algorithm in the treatment of traumatic brain injury (TBI) as cerebral resuscitation is shown in below diagram.

This algorithm covers normovolemia maintenance, seizure prophylaxis, artificial ventilation, ICP monitoring, PaCO2 maintenance, and hypertonic saline alternative osmotherapy besides mannitol usage.
Cerebral Resuscitation in Traumatic Brain Injury Algorithm Diagram can be completely seen in pdf.
