Here we provide you with an article which discusses the pathogenesis of the coagulopathy of sepsis and also the approaches in correcting the defect in the coagulation system since sepsis is a series of inflammatory and hemostatic alterations that occur in response to systemic infection. A severe condition associated with acute organ failure.
As seen in the diagram, it views coagulation occurs on different cell surfaces in three overlapping phases. There are:
- Initiation,
…takes place on tissue factor-bearing cells. Once a sufficiently strong procoagulant stimulus is generated, enough factors Xa, IXa and thrombin are formed to initiate the coagulation process…
2. Amplification,
…as platelets adhere to the initiation site, they become activated and accumulate co-factors on their surfaces amplifying the procoagulant stimulus…
3. Propagation,
…active proteases combine with their co-factors on the surfaces of activated platelets, and through the generation of a burst of thrombin, propagate the procoagulant process, resulting in fibrin polymerization…
Further description on The Pathogenesis and Treatment of the Coagulopathy of Sepsis can be download here in pdf filetype (source: ima.org.il).
