Liver fibrosis is a dynamic process resulting in excessive deposition of extracellular matrix (ECM) components. It is considered a common response to many chronic hepatic injuries which involves several cell types, cytokines, chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem.
The picture shows you with diagram of activated hepatic stellate cell actions and interactions in liver fibrosis process (HSC: Hepatic stellate cell; KC: Kupffer cell; APR: Acute phase response; ECM: Extracellular matrix; TGFβ: Transforming growth factor-β).
Completed explanation about Activated Hepatic Stellate Cell Diagram in Liver Fibrosis Process can be found in this pathogenesis pdf journal, and find informations about Renin Angiotensin System’s role in hepatic fibrosis (source: wjgnet.com)
